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Further clinical evidence is needed to clarify their role, optimise treatment strategies, and assess their impact on disease progression and patient outcomes

The STEP-1 trial data shows the dose-response relationship clearly: 0.25 mg: Minimal weight loss (2-3% over 68 weeks), used only for adaptation 0.5 mg: 6.4% average weight loss 1 mg: 10.9% average weight loss 1.7 mg: 13.8% average weight loss 2.4 mg: 15.8% average weight loss Each escalation produces incremental benefit, but the jumps get smaller as you approach maximum dose

This concept opens the door to investigating other yet unexplored pathways involved in metabolic dysfunction-associated steatotic liver disease (MASLD) development

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Before starting GLP-1 medications: Ensure you've had a recent diabetic eye screening (within the past 12 months) Discuss your retinopathy status with your prescribing clinician If you have known retinopathy, consider ophthalmology review before initiation Understand that gradual dose titration may help avoid very rapid changes in blood glucose, which is a general principle in diabetes management During treatment: Attend all scheduled diabetic eye screening appointments without fail If you have pre-existing retinopathy, your diabetes team may consider more frequent monitoring based on your individual clinical situation Control blood pressure to target levels (below 140/90 mmHg, or below 130/80 mmHg if you have kidney, eye or cerebrovascular damage, if tolerated) [13] Maintain good overall glycaemic control whilst avoiding excessively rapid HbA1c reductions when possible Stop smoking if applicable, as tobacco significantly worsens diabetic eye disease Manage cholesterol levels according to NICE guidance for cardiovascular risk reduction Communicate openly with your healthcare team about any visual symptoms, even if they seem minor